Technische Universiteit Delft, Delft, The Netherlands (TUDelft)
Contact information
F. Hollmann, Department of Biotechnology, Delft University of Technology, Julianalaan 136, 2628BL Delft, The Netherlands
Phone: +31 15 2781957
E-mail:
f.hollmann@tudelft.nl
Description of the group
The “Biocatalysis and Organic Chemistry Group” (
www.bt.tudelft.nl/boc) headed by Prof.
I.W.C.E. Arends aims at discovery, design and engineering of novel enzymatic pathways leading to target products. To strengthen the focus in the application-oriented research, the understanding of the effect of immobilization (stability as well as compartmentalization) of enzymes is a central research line. The
infrastructure of BOC can be described as a combination of base organic chemistry and molecular biology laboratories. In addition, spectroscopy facilities, such as NMR, and EPR are present within the group. For screening of enzymes, a dedicated laboratory is available, that allows performing high-throughput production and assaying of enzymes at advanced safety levels.
Dr.
Frank Hollmann will be the scientist in charge o the contribution to
INDOX (supported by staff of the Department of Biotechnology). Dr.
Hollmann is an internationally renowned expert for the use of enzymes in organic synthesis. His research interests span diverse classes of oxidoreductases for preparative oxidation/reduction and oxyfunctionalization chemistry.Prof.
Arends will be also actively involved in the project. In addition Prof.
Hanefeld (biocatalysis), Dr.
L. Otten (enzyme production), Dr.
A Straathof (modeling, reactor design) will be available for consultation.
Main role in INDOX
The group will be active in (and leading) actions in
WP7, working on optimization of enzymatic reactions towards industrial application, and will also collaborate in oxyfunctionalization studies and process up-scaling. Hence,
TUDelft will act as facilitator between the groups discovering and optimizing new enzymes and the industrial partners wanting to commercialize these enzymes.