Optimized oxidoreductases for medium and large scale industrial biotransformations
Project Secretariat
Dr Marta Pérez-Boada
E-mail: MPBoada@cib.csic.es
Consejo Superior de Investigaciones Científicas (CSIC)
Biological Research Centre (CIB)
Calle Ramiro de Maeztu 9, E-28040 Madrid, Spain
Phone: 34 918373112
Fax: 34 915360432
Mobile: 34 650080476
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about us
URWageningen University, Wageningen, The Netherlands (WUR)

W.J.H. van Berkel
Contact information
W.J.H. van Berkel, Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA Wageningen, The Netherlands.

Phone: 31 317 282861
Fax: 31 317 484801
E-mail: willem.vanberkel@wur.nl.

Description of the group
The group (www.bic.wur.nl) has wide expertise in oxidative enzymes of biotechnological interest. It is part of the Agro-Food Sciences Group (AFSG) of Wageningen University and Research Centre (WUR), the main institutefor Food and Health research in The Netherlands.

Adrie Westphal

Gudrun Gygli

Tom Ewing
The contribution to INDOX will be led by Prof. Dr. Willem J.H. van Berkel, who has large experience in flavoenzymes and other redox systems (molecular enzymology, applied biocatalysis; synthetic biology) resulting in ~245 publications (papers, patents and chapters). Other members of the group indirectly participating in the project are: Dr Carlo P.M. van Mierlo, assistant professor with ~60 publications, who works on protein folding and stability; Dr. Jan-Willem Borst, assistant professor with ~60 publications, who works on protein fluorescence spectroscopy; Ing. Adrie H. Westphal, research assistant with ~70 publications, who works on molecular biology and biochemistry of flavoproteins;andseveral PhD students working on flavoproteins (Joseline Houtman, Antsje Nolles and Mieke Huijbers).
Main role in INDOX

Flavo Beads
The WUR participation will focus on alcohol oxidases of the VAO family by considering: i) exploitation of natural diversity; ii) protein engineering to increase of operational stability by rational design and directed evolution; and iii) optimization of formation of interesting products. WUR is the leader of WP2 devoted to the discovery, biochemical and structural-functional studies of VAO family flavo-oxidases.
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Project Coordinator
Prof. Angel T. Martínez
Biological Research Centre (CIB, CSIC)
Calle Ramiro de Maeztu 9, E-28040 Madrid, Spain.
E-mail: ATMartinez@cib.csic.es
Phone: 34 918373112
Fax: 34 915360432

Angel T. Martínez is Research Professor of CSIC at the group of Biotechnology for Lignocellulosic Biomass of CIB. He is member of ACS, ASM and TAPPI, with around 250 publications mainly related to oxidoreductases and microbial biotechnology.

His experience is supported by participation in more than 55 national and international research projects, in most of them as head researcher. Regarding EC Framework Programmes, he has coordinated projects of Industrial Biotechnology from FP3 to FP7, such as PEROXICATS (KBBE-2010-4-265397), BIORENEW (NMP2-CT-2006-026456), PELAS (QLK3-1999-00590), PITCH (QLK5-1999-01357) and AIR2 (CT93-1219).
Official webpage of indox [ industrialoxidoreductases ]. Optimized oxidoreductases for medium and large scale industrial biotransformations. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under Grant Agreement nº: FP7-KBBE-2013-7-613549. © indox 2013. Developed by garcíarincón