Optimized oxidoreductases for medium and large scale industrial biotransformations
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126
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[ 2014 ]
González-Pérez D, Molina-Espeja P, García-Ruiz E, Alcalde M Mutagenic Organized Recombination Process by Homologous In vivo Grouping (MORPHING) for directed enzyme evolution
PlosOne, 9: 3
[ 2014 ]
Hofrichter M, Ullrich R Oxidations catalyzed by fungal peroxygenases
Curr. Opin. Chem. Biol., 19: 116-125
[ 2014 ]
Hori C, [...] , Ferreira P, Ruiz-Dueñas FJ, [...] , Rencoret J, Gutiérrez A, [...] , Martínez AT, [...] , Cullen D Analysis of the Phlebiopsis gigantea Genome, Transcriptome and Secretome Provides Insight into Its Pioneer Colonization Strategies of Wood
PLOS Genetics, 10: 1004759
[ 2014 ]
Isaksen T, Westereng B, Aachmann FL, Agger JW, Kracher D, Kittl R, Ludwig R, Haltrich D, Eijsink VG, Horn SJ A C4-oxidizing lytic polysaccharide monooxygenase cleaving both cellulose and cello-oligosaccharides
J. Biol. Chem., 289: 2632-2642
[ 2014 ]
Kalum L, Morant MD, Lund H, Jensen J, Lapainaite I, Soerensen NH, Pedersen S, Ostergaard LH, Xu F Enzymatic oxidation of 5-hydroxymethylfurfural and derivatives thereof. WO 2014015256 A2.
International Patent Application
[ 2014 ]
Kellner H, Luis P, Pecyna MJ, Barbi F, Kapturska D, Krüger D, Zak DR, Marmeisse R, Vandenbol M, Hofrichter M Widespread Occurrence of Expressed Fungal Secretory Peroxidases in Forest Soils
PlosOne, 9
year2014
Oxidations catalyzed by fungal peroxygenases
Hofrichter M, Ullrich R
Curr. Opin. Chem. Biol., 19: 116-125
The enzymatic oxyfunctionalization of organic molecules under physiological conditions has attracted keen interest from the chemical community. Unspecific peroxygenases (EC 1.11.2.1) secreted by fungi represent an intriguing enzyme type that selectively transfers peroxide-borne oxygen with high efficiency to diverse substrates including unactivated hydrocarbons. They are glycosylated heme-thiolate enzymes that form a separate superfamily of heme proteins. Among the catalyzed reactions are hydroxylations, epoxidations, dealkylations, oxidations of organic hetero atoms and inorganic halides as well as one-electron oxidations. The substrate spectrum of fungal peroxygenases and the product patterns show similarities both to cytochrome P450 monooxygenases and classic heme peroxidases. Given that selective oxyfunctionalizations are among the most difficult to realize chemical reactions and that respectively transformed molecules are of general importance in organic and pharmaceutical syntheses, it will be worth developing peroxygenase biocatalysts for industrial applications.
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[ industrialoxidoreductases ]. Optimized oxidoreductases for medium and large scale industrial biotransformations. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under Grant Agreement nº: FP7-KBBE-2013-7-613549. © indox 2013. Developed by
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